| Hertz | Estero | 1918 |
| Hess Corporation | Nova Iorque | 1919 |
| Hewlett-Packard | Palo Alto | 2 de julho de 1939 |
| HGST | São José | 2003 |
| Hiller Aircraft Company | Firebaugh | 1942 |
| Holland America Line | Seattle | 1873 |
| Honeywell | Charlotte | 23 de abril de 1885 |
| Honeywell Aerospace | Phoenix | 1936 |
| Hormel | Austin | 1891 |
| Hornady | Grand Island | 1949 |
| House of Blues | Los Angeles | 26 de novembro de 1992 |
| HowStuffWorks | Atlanta | 11 de julho de 1998 |
| HRG Group | Rochester | 1953 |
| Hudson Motor Car Company | Detroit | 1909 |
| Humana | Louisville | 1961 |
| Huntington Bancshares | Columbus | 1866 |
| Huntington Ingalls Industries | Newport News | 31 de março de 2011 |
| Huntsman Corporation | Salt Lake City | 1982 |
| Hy-Vee | West Des Moines | 1930 |
| Hyperion Solutions | Santa Clara | 1981 |
| Hyperloop One | Los Angeles | junho 2014 |
| IAC | Nova Iorque | 28 de julho de 1986 |
| IBM Cloud Video | São Francisco | 2007 |
| IBM Research | — | 1945 |
| Id Software | Richardson | 1 de fevereiro de 1991 |
| IFixit | San Luis Obispo | 2003 |
| Illinois Tool Works | Glenview | 1912 |
| Impossible Foods | Redwood City | 2011 |
| Incyte | Wilmington | 2001 |
| IndyMac | Pasadena | 16 de julho de 1985 |
| Infor | Nova Iorque | 2002 |
| Informática | Redwood City | fevereiro 1993 |
| Instacart | São Francisco | 2012 |
| Instituto de Engenheiros de Rádio | — | 1912 |
| Intercontinental Exchange | Atlanta | 11 de maio de 2000 |
| International Flavors & Fragrances | Nova Iorque | 1958 |
| International Swaps and Derivatives Association | Nova Iorque | — |
| Intuit | Mountain View | 1983 |
| Intuitive Surgical | Sunnyvale | 1995 |
| Invesco | Atlanta | 1935 |
| Iomega | San Diego | 1980 |
| Ion Storm | Austin | 1996 |
| IQVIA Holdings, Inc. | Danbury, Durham | 2016 |
| IRobot | Bedford | 1990 |
| Ithaca Gun Company | Upper Sandusky | 1880 |
| ITT Corporation | Stamford | 1920 |
| J. B. Hunt | Lowell | 1961 |
| J.Crew | 225 Liberty Street | 1983 |