| Dyn | Manchester | 1998 |
| Dynetics | Huntsville | 1974 |
| E-Trade | Nova Iorque | 1982 |
| E. Remington and Sons | Estados Unidos | 1816 |
| EA Sports | Burnaby | 1991 |
| EBSCO Information Services | Birmingham | 1943 |
| Ecolab | Saint Paul | 1923 |
| EDS | Plano | 27 de junho de 1962 |
| Einstein Bros. Bagels | Lakewood | 1995 |
| Eldeman | Nova Iorque | 1952 |
| Elevance Health | Indianápolis | 2004 |
| Elliott Management Corporation | Nova Iorque | 1977 |
| Energizer | St. Louis | 2000 |
| Energy Transfer | Dallas | 1996 |
| EnterpriseDB | Bedford | março 2004 |
| Epicor | Austin, Irvine | 1972 |
| Epiphone | Nashville | 1873 |
| Epyx | São Francisco | 1978 |
| ESPN+ | Estados Unidos | 12 de abril de 2018 |
| ESPN, LLC | Bristol | 7 de setembro de 1979 |
| Eurasia Group | Nova Iorque | 1998 |
| Exidy | Sunnyvale | 1974 |
| Expand Energy | Oklahoma City | 1989 |
| Expedia | Seattle | 22 de outubro de 1996 |
| Extreme Championship Wrestling | Filadélfia | 25 de abril de 1992 |
| Exxon | Las Colinas | 1 de janeiro de 1973 |
| ExxonMobil | Spring | 5 de agosto de 1882 |
| Fageol | Oakland | 1916 |
| Fandango (empresa) | Los Angeles | 2000 |
| Fannie Mae | Noroeste de Washington, D.C. | 1938 |
| Fantasy Flight Games | Roseville | 1995 |
| Farmers Insurance Group | Wilshire Boulevard, Los Angeles | 1928 |
| Fastenal | Winona | 1967 |
| Federal Home Loan Banks | Boston, Chicago, Pittsburgh, Dallas, Atlanta, Des Moines, Topeka, Cincinnati, Nova Iorque, São Francisco, Indianápolis | 1932 |
| FEI Company | Hillsboro | 1971 |
| Fenway Sports Group | Boston | 2001 |
| Fidelity Investments | Boston | 1946 |
| Firebase | São Francisco | 2010 |
| First Citizens BancShares | Raleigh | 7 de agosto de 1986 |
| Fisher-Price | Nova Iorque | 19 de junho de 1930 |
| Florsheim Shoes | Glendale | 1892 |
| Fluor Corporation | Irving | 1890 |
| Fodera | Nova Iorque | 1983 |
| Ford Aerospace | Milpitas | 1956 |
| Ford Racing | Dearborn | — |
| Forrester Research | Cambridge | 1983 |
| Fortune Brands | Deerfield | 1969 |
| Fox 2000 Pictures | Century City | 7 de janeiro de 1994 |