| Similarweb | Givatayim | 2007 |
| Singularity University | Mountain View | 2010 |
| Sirius Satellite Radio | Nova Iorque | 17 de maio de 1990 |
| Six Flags | Arlington | 1961 |
| Six Flags | Charlotte | 1 de julho de 2024 |
| Skechers | Manhattan Beach | 1992 |
| Slack Technologies | São Francisco | 2009 |
| Smithfield Foods | Smithfield | 1936 |
| Snap Inc. | Santa Mônica, Venice | 16 de setembro de 2011 |
| Sociedade de Criação de Língua | Garden Grove | 2007 |
| Sony Imagesoft | Los Angeles | 1989 |
| Sony Music | Nova Iorque | 1 de janeiro de 2009 |
| Sony Pictures Imageworks | Vancouver, Montreal | 1992 |
| Sony Pictures Motion Picture Group | Culver City | 1998 |
| Southern Company | Atlanta | 1945 |
| Soylent | Los Angeles | 2013 |
| SpaceX | Starbase | 14 de março de 2002 |
| Spanx | Atlanta | 2000 |
| Spectravideo | — | 1981 |
| Springfield Armory | Geneseo | 1974 |
| Standard Oil Company | Ohio, Cleveland, Nova Iorque | 1890 |
| Stanley Black & Decker | New Britain | 1843 |
| Starwood | White Plains | 1930 |
| Stellantis North America | Chrysler Headquarters and Technology Center | 28 de abril de 2009 |
| Strategic Simulations | Sunnyvale | 1979 |
| Stratfor | Austin | 1996 |
| Stüssy, Inc. | Irvine | 1980 |
| SugarCRM | Cupertino | 2004 |
| Sunkist Growers | Los Angeles | 29 de agosto de 1893 |
| Supermicro | São José | 1993 |
| Supreme | Nova Iorque | abril 1994 |
| SurveyMonkey | San Mateo | 1999 |
| Synopsys | Mountain View | 1986 |
| T. Rowe Price | Baltimore | 1937 |
| TBWA Worldwide | Nova Iorque | 1970 |
| Tennessee Valley Authority | Knoxville | 1933 |
| Tesla | Austin | 1 de julho de 2003 |
| The Athletic | São Francisco | janeiro 2016 |
| The Bank of New York Mellon | Nova Iorque | 2007 |
| The Behemoth | San Diego | 2003 |
| The Cigna Group | Bloomfield | 1982 |
| The Jim Henson Company | Hollywood | 1958 |
| The Leading Hotels of the World | Nova Iorque | 1928 |
| The McClatchy Company | Sacramento | 1857 |
| The Mosaic Company | Plymouth | 2004 |
| The NPD Group | Port Washington | 1967 |
| The Orchard | Nova Iorque | 1997 |
| The Salt Lake Tribune | — | 1870 |