| Real3D | Orlando | 1986 |
| RealNetworks | Seattle | 1993 |
| Realty Income | San Diego | 1969 |
| Red Hat | Raleigh | 27 de março de 1993 |
| Redback Networks | São José | 1996 |
| Regeneron Pharmaceuticals | Eastview | 1988 |
| Regent Seven Seas Cruises | Miami | 1990 |
| Renaissance Technologies | Setauket-East Setauket | 1982 |
| Replit | São Francisco | — |
| Republic Airways Holdings | Indianápolis | 1973 |
| Revell | Elk Grove Village | 1943 |
| Revolution Studios | Los Angeles | 2000 |
| Richard Childress Racing | — | 1969 |
| Rivian | Detroit | junho 2009 |
| Robinhood | Palo Alto | 2013 |
| Robinson Helicopter | Zamperini Field | 1973 |
| Rocketdyne | Canoga Park | 2005 |
| Rocketdyne | Los Angeles | 1955 |
| Rogers Locomotive and Machine Works | — | 1832 |
| Rohm and Haas | Filadélfia | 1 de setembro de 1909 |
| Rotten Tomatoes | São Francisco | 19 de agosto de 1998 |
| Roxio | Santa Clara | 2001 |
| Royal Caribbean Group | Miami | 1997 |
| RR Donnelley | Chicago | 1864 |
| Saatchi & Saatchi | Nova Iorque | 1970 |
| SAE International | Warrendale | 1905 |
| Safeway | Pleasanton | 1915 |
| Saks Fifth Avenue | Nova Iorque | 1898 |
| Salesforce | Salesforce Tower, São Francisco | 3 de fevereiro de 1999 |
| Schwinn | Chicago | 1895 |
| Scribd | São Francisco | março 2006 |
| Scripps-Booth | Detroit | 1913 |
| Sealy Corporation | Trinity | 1881 |
| Sears Holdings Corporation | Hoffman Estates | 2005 |
| SeaWorld | Orlando | 21 de março de 1964 |
| Semrush | Boston | 3 de agosto de 2008 |
| Sequential Circuits | São José | 1970 |
| Seymour Duncan | Goleta | 1978 |
| Shelby SuperCars | West Richland | 1999 |
| Shen Yun | Deerpark | 2006 |
| Sheraton Hotels & Resorts | White Plains | 1937 |
| Shield AI | San Diego | 28 de maio de 2015 |
| Shiny Entertainment | Laguna Beach, Newport Beach | 1993 |
| Shure | Niles | 1925 |
| Sierra Nevada Corporation | Sparks | 1963 |
| Sigma-Aldrich | St. Louis | 1976 |
| Silicon Laboratories | Austin | 1996 |
| Silver Lake | Menlo Park | 1999 |