| Biogen Idec | Cambridge | 1978 |
| Blinding Edge Pictures | Berwyn | 1999 |
| Block, Inc. | São Francisco | fevereiro 2009 |
| Bluehost | Provo | 2022 |
| Blur Studio | Venice | 1995 |
| BMC Software | Houston | 1980 |
| BMG Rights Management | Quartier 205 | 1 de outubro de 2008 |
| Bobcat Company | West Fargo | 1947 |
| Booz Allen Hamilton | Tysons Corner | 1914 |
| BorgWarner | Auburn Hills | 1880 |
| Boston Scientific | Marlborough | 29 de junho de 1979 |
| Brink's | Condado de Henrico | 1859 |
| Broadcom | Irvine | agosto 1991 |
| Broadcom | Palo Alto | 1961 |
| Brocade Communications Systems | São José | 1995 |
| Brooklyn–Manhattan Transit Corporation | Brooklyn | 1923 |
| Brooks Brothers | Nova Iorque | 1818 |
| Brown-Forman | Louisville | 1870 |
| Browning (empresa) | Morgan | 1927 |
| Bucyrus International | South Milwaukee | 1880 |
| Budd Company | Filadélfia | 1912 |
| Budget | Chicago, Parsippany-Troy Hills | 1958 |
| Bulova | Nova Iorque | 1875 |
| Burger Chef | Indianápolis | 1954 |
| Burlington | Florence | 1972 |
| Burroughs Corporation | Detroit, Missouri, St. Louis | 1904 |
| Burt's Bees | Durham | 1984 |
| BuzzFeed | Nova Iorque, Nova Iorque | 2006 |
| C. H. Robinson Worldwide | Eden Prairie | 1905 |
| C.F. Martin & Company | Nazareth | 1833 |
| Cabot Corporation | Boston | 1882 |
| Cadence Design Systems | São José | 1988 |
| Canadian Solar | — | 2001 |
| Cannon Films | Estados Unidos | 23 de outubro de 1967 |
| Cannondale Bicycle Corporation | Bethel | 1971 |
| Canoo | Torrance | 2017 |
| Capital One | McLean | 1994 |
| Cargill | Minnetonka | 1865 |
| Carhartt | Dearborn | 1889 |
| Carlson Wagonlit Travel | Minneapolis | 1994 |
| Carlyle Group | Washington, D.C. | 1987 |
| CarMax | condado de Goochland | 1993 |
| Carnival Corporation & plc | Doral, Southampton, Flórida, Londres, Miami | 1972 |
| Cartercar Company | Pontiac | 1905 |
| Cash App | — | 15 de outubro de 2013 |
| Caterpillar Inc. | Irving | 1925 |
| Celera Corporation | Rockville, Alameda | maio 1998 |
| Celgene | Summit | 1986 |