| Odyssey Marine Exploration | Tampa | 1994 |
| Office Depot | Boca Raton | 1986 |
| Orbital Sciences Corporation | Dulles | 1982 |
| OTC Markets Group | Nova Iorque | 1913 |
| Owens-Illinois | Toledo, Perrysburg | 1903 |
| Paccar | Bellevue | 1905 |
| Pacific Gas and Electric Company | Pacific Gas & Electric Building, São Francisco | 1905 |
| Panera Bread | Sunset Hills | 1987 |
| Papa John's Pizza | Louisville | 2 de outubro de 1984 |
| Peabody Energy | St. Louis | 1883 |
| Plantronics | Santa Cruz | 1961 |
| Plug Power | Latham, Slingerlands | 1997 |
| Polaris Industries | Medina | 1954 |
| Polycom | São José | 1990 |
| PPG Industries | Pittsburgh | 1883 |
| Procter & Gamble | Ohio, Cincinnati | 31 de outubro de 1837 |
| Prudential Financial | Prudential Headquarters | 1875 |
| Qorvo | Greensboro | 2015 |
| Qualcomm | San Diego | julho 1985 |
| Qualtrics | Provo | 2002 |
| Rackspace Technology | — | 1998 |
| Rayovac | Middleton | 1906 |
| Raytheon | Waltham | 7 de julho de 1922 |
| Razer | George Town, Singapura, Carlsbad, Irvine, São Francisco | 1998 |
| Realty Income | San Diego | 1969 |
| Red Hat | Raleigh | 27 de março de 1993 |
| Red Robin | Greenwood Village | 1940 |
| Regeneron Pharmaceuticals | Eastview | 1988 |
| Republic Airways Holdings | Indianápolis | 1973 |
| Rivian | Detroit | junho 2009 |
| Robinhood | Palo Alto | 2013 |
| Rockwell International | Estados Unidos | fevereiro 1973 |
| Rocky Mountain Chocolate Factory | Durango | 1981 |
| Royal Caribbean Group | Miami | 1997 |
| RR Donnelley | Chicago | 1864 |
| Safeway | Pleasanton | 1915 |
| Salesforce | Salesforce Tower, São Francisco | 3 de fevereiro de 1999 |
| Sealy Corporation | Trinity | 1881 |
| Sears Holdings Corporation | Hoffman Estates | 2005 |
| Semrush | Boston | 3 de agosto de 2008 |
| SFX Entertainment | Burbank | 10 de março de 2014 |
| Sigma-Aldrich | St. Louis | 1976 |
| Silicon Laboratories | Austin | 1996 |
| Similarweb | Givatayim | 2007 |
| Six Flags | Arlington | 1961 |
| Six Flags | Charlotte | 1 de julho de 2024 |
| Skechers | Manhattan Beach | 1992 |
| Slack Technologies | São Francisco | 2009 |